The State of Missouri has been divided into 11 regions for the purpose of Homeland Security planning; these regions are based on the existing 9 State Highway Patrol regions with the addition of regions for the St. Louis and Kansas City metro areas.

Region F RHSOC includes Audrain, Boone, Callaway, Camden, Cole, Cooper, Gasconade, Howard, Miller, Moniteau, Montgomery, Morgan, and Osage counties (see map on sidebar).

The Mid-Missouri Regional Planning Commission (Mid-MO RPC) is the Lead RPC for Region F RHSOC and is responsible for assisting the RHSOC in developing a planning process to assess, evaluate, identify, and prioritize existing and needed Homeland Security assets, in conjunction with the Department of Public Safety.  This planning process is used as a basis for funding and policy recommendations from the region.

The other Regional Planning Commissions involved in the Region F RHSOC are Boonslick Regional Planning Commission, Lake of the Ozarks Council of Governments, Mark Twain Regional Council of Governments, and Meramec Regional Planning Commission.